It followed a turbulent night with Remain campaigners quietly confident until the early hours when results from Newcastle and Sunderland showed better than expected returns for the Brexit camp, reports The Telegraph.
A surprise victory for a Brexit in Swansea, which was expected to vote to Remain, did little to dampen concerns despite Scotland overwhelmingly backing staying in the Union.
Other votes in Wales began to show a trend towards a surprise Leave vote, particularly in deprived communities.
Big wins for David Cameron’s campaign in London and Oxford did little to allay fears that early predictions had been wrong, as the pound began to tank – down by 6 per cent by around 1pm.
Leave passed the finishing post just after 6am, as it became clear that nothing could swing the vote back in favour of the Remain campaign.
With the Leave campaign securing 52 per cent of the vote, Mr Cameron addressed the nation in an emotional speech outside 10 Downing Street to announce that he would be stepping down.
Statements are expected to be made by Sinn Fein and the SNP later today calling for a breakaway from the Union. London backed Remain but the turnout was lower than expected because of bad weather.
Meanwhile on the market, the FTSE 250 index has plunged a whopping 11.7 per cent. The index of so-called mid-cap companies had dropped an astonishing 2,017 points to 15,309 in the first few minutes of trading.